HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ibuprofen, (+-)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 3-(2-Methylpropyl)cyclohexan-1-one | HCID 12528502 | — |
| Reactant | Sodium pyruvate | HCID 23662274 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Ibuprofen, (+-)- | HCID 3672 | — |
Reaction Steps
The process according to claim 1, wherein 3-isobutyl-cyclohexanone and sodium pyruvate are heated in a HCl and acetic acid solution to give a mixture of condensation products and said condensation products are heated for 4 to 5 hours with pyridine hydrochloride to give p-isobutylhydratropic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04154962 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-7449d7e547074f82a03627cc30393c1b |
| Source note | uspto-grants-1979_05 |