Phosgene → 4,6-Dimethoxyisatoic anhydride

HRID 262830Notes

Reaction equation

HRID 262830 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:14])[C:6](=[C:10]([O:12][CH3:13])[CH:11]=1)[C:7]([OH:9])=[O:8].[C:15](Cl)(Cl)=[O:16]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[NH:14][C:15](=[O:16])[O:9][C:7](=[O:8])[C:6]2=[C:10]([O:12][CH3:13])[CH:11]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 116584562-Amino-4,6-dimethoxybenzoic acid

Product 1

HCID 116010104,6-Dimethoxyisatoic anhydride

Procedure

4,6-Dimethoxyisatoic anhydride is prepared from 4,6-dimethoxyanthranilic acid (H. Newman and R. Anzier, J. Org. Chem. 34, 3484 (1969)) and phosgene according to the method of E. C. Wagner and M. F. Fegley, Org. Synthesis 27, 45 (1947).

Workup

  1. customSynthesis 27, 45 (1947)

Sources & evidence

ORD record
ord-9777f7c479d3490183503cb6ee1f6868
Source dataset
uspto-grants-1979_05
Patent number
US04154961

Reaction notes

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