HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 262917Generated: October 25, 2026
Sulfuric Acid → Methyl 4-(4-aminophenyl)-4-oxobutanoate
https://huagongshe.com/reaction/262917
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-(4-Acetamidophenyl)-4-oxobutanoic acid | HCID 232337 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-(4-aminophenyl)-4-oxobutanoate | HCID 12016833 | — |
Reaction Steps
A mixture of 35 g. of 3-p-acetamidobenzoylpropionic acid, 700 ml. of methanol and 1.4 ml. of concentrated sulfuric acid is refluxed for 76 hours. The solution is cooled to 35° C. and poured onto 7 g. of anhydrous sodium acetate while stirring. The reaction mixture is stirred in an ice-bath. The product is filtered and washed with cold methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04154756 |
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| Source dataset | uspto-grants-1979_05 |
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| ORD ID | ord-a397ab3389eb43658d952e0a405cb63c |
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| Source note | uspto-grants-1979_05 |
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