反应详情

A solution of 10 g. of 13,13-dimethyltetradecyl bromide and 10.8 g. of ethyl 4-aminobenzoate in 75 ml. hexamethylphosphoramide is heated at 110° C. for 17 hours. The cooled solution is diluted with 100 ml. water, filtered, and the residue is washed in portions with 100 ml. 50% ethanol-water. After drying, the product is crystallized from ethanol-water. After drying, the product is crystallized from ethanol to yield ethyl 4-(13,13-dimethyltetradecyl)aminobenzoate as colorless crystals.

1. additionThe cooled solution is diluted with 100 ml
2. filtrationwater, filtered
3. washthe residue is washed in portions with 100 ml
4. customAfter drying
5. customthe product is crystallized from ethanol-water
6. customAfter drying
7. customthe product is crystallized from ethanol