Benzocaine → HCID 21318765, compound

Participants

Reaction Steps

A solution of 15 g. (43.2 mmoles) 11-oxo-15,15-dimethylhexadecyl bromide and 14.3 g. (2 eq.) ethyl 4-aminobenzoate in 100 ml. hexamethylphosphoramide is heated at 120° C. for 18 hours. The cooled solution is diluted with 200 ml. water and filtered. The resultant solid is washed in portions with 200 ml. 50% ethanol-water, dried, and crystallized from ethanol to yield a colorless, waxy solid.

Provenance & Evidence