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p-Toluenesulfonic acid → 3-(3-Chloro-4-isopropyl-phenyl)-5-methyl-tetrahydro-1,3,5-oxadiazin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Urea, 3-(3-chloro-p-cumenyl)-1,1-dimethyl- | HCID 182166 | — |
| 反応物 | HCID 178486302 | HCID 178486302 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 3-(3-Chloro-4-isopropyl-phenyl)-5-methyl-tetrahydro-1,3,5-oxadiazin-4-one | HCID 21317062 | — |
反応手順
N-(3-Chloro-4-isopropyl-phenyl)-N',N'-dimethylurea (22.65 g.=0.1 mol) is dissolved in a solvent mixture comprising dioxane (50 cc.) and benzene (80 cc.). After adding p-toluenesulphonic acid (1 g.) and polyoxymethylene (8.1 g.), the solution is heated under reflux for 1 hour in a flask equipped with a Dean and Stark apparatus with a reflux condenser. 3.7 cc. of aqueous phase are collected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04155747 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-3baba906511849bd9ab44f03dbbc55e8 |
| 出典メモ | uspto-grants-1979_05 |