HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 2-Cyano-2-isopropyl-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-Methyl-2-(propan-2-yl)butanenitrile | HCID 13699841 | — |
| Product | 2-Cyano-2-isopropyl-3-methylbutanoic acid | HCID 348277 | — |
Reaction Steps
Thus, MARSHALL prepares diisopropyl acetonitrile from a cyanacetic ester, by treating with sodium an alcoholic solution of this ester and by causing this mixture to react for several hours with an excess of isopropyl iodide. The monoalkylated product is eliminated by means of a 10% sodium hydroxide solution and the crude dialkyl ester obtained by this procedure is then treated with a 35% potassium hydroxide solution for 16 hours. After acidification, the diisopropyl cyanacetic acid obtained is decarboxylated by distillation in the presence of twice its weight of molten potassium hydroxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04155929 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-fd61993307604e76b794bb957af16dc1 |
| Source note | uspto-grants-1979_05 |