Hydrochloric Acid → HCID 21317683, compound

Participants

Reaction Conditions

Reaction Steps

0.35 g of 2-(2-acetylhydrazino)-7-chloro-5-(2,6-difluorophenyl)-3H-thieno[2,3-e]-1,4-diazepine are distributed on a metal plate in as thin as possible a layer and maintained at 270° C. for 1 minute in a sand bath. The melt is taken up in methylene chloride and shaken three times with 0.1-N hydrochloric acid in order to remove the starting material. The methylene chloride is distilled off and the product recrystallized from ethyl acetate containing active carbon. There is obtained 2-chloro-4-(2,6-difluorophenyl)-9-methyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine, melting point 185°-187° C.

Provenance & Evidence