2-chloro-4-(o-chlorophenyl)-9-(alpha-hydroxyethyl)-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine → 9-acetyl-2-chloro-4-(o-chlorophenyl)-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine

Participants

Reaction Steps

0.4 g of 2-chloro-4-(o-chlorophenyl)-9-(α-hydroxyethyl)-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine are boiled under reflux for 48 hours in 80 ml of dry toluene with 0.6 g of chromtrioxide embedded in graphite. The solid material is filtered off and the solution evaporated. The residue is recrystallized from ethanol, there being obtained 9-acetyl-2-chloro-4-(o-chlorophenyl)-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine of melting point 89°-91° C.

Provenance & Evidence