HCID 23338136, compound → HCID 21317998, compound

HRID 263046Notes

Reaction equation

HRID 263046 reaction equation
[CH:1]([N:4]1[C:9](=[O:10])[NH:8][CH:7](SC)[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].C(O)(=O)C.[CH:18]1([NH2:21])[CH2:20][CH2:19]1>O>[CH:1]([N:4]1[C:9](=[O:10])[NH:8][CH:7]([NH:21][CH:18]2[CH2:20][CH2:19]2)[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 23338136HCID 23338136, compoundHCID 68569522HCID 68569522, compound

Product 1

HCID 21317998HCID 21317998, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

1-Isopropyl-4-methylthiotetrahydro-1,3,5-triazine-2,6-dione (6.0 g.) (obtained as described in U.K. patent specification No. 1,435,585) and cyclopropylamine acetate (17.85 g.) were heated together and stirred at 150° C. for 3 hours. The mixture was then cooled and water (150 ml.) was added. The white solid which formed was collected, washed with water and dried to give 1-isopropyl-4-cyclopropylaminotetrahydro-1,3,5-triazine-2,6-dione, m.p. 237°-239° C.

Workup

  1. temperatureThe mixture was then cooled
  2. customThe white solid which formed
  3. customwas collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-115ca8bff4ec48f19ba32f8d054af56c
Source dataset
uspto-grants-1979_05
Patent number
US04156002

Reaction notes

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