Acetic Acid → HCID 86736555, compound

Participants

Reaction Steps

A solution of 238 mg. (0.5 mmol) of α-cyano-α-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenylazo]benzenepropanoic acid ethyl ester in 3 ml. of acetic acid and 1 ml. of concentrated hydrochloric acid was stirred at room temperature for 30 minutes, diluted with water, made basic with sodium bicarbonate and extracted with ether. The ether extracts were dried and concentrated. The residue was dissolved in 1:1 benzene-dichloromethane and passed over a little silica gel. The eluate was concentrated and crystallized from hexane to give α-[1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]hydrazin-2-ylidene]benzenepropanenitrile Isomer A as yellow crystals, m.p. 90°-92°.

Provenance & Evidence