Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 21318061, compound

HRID 263089Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Br[C:10]([CH3:17])([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:10]([CH3:17])([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl ester

HCID 660494-Bromothiophenol

Product 1

HCID 21318061HCID 21318061, compoundYield 90%

Procedure

Following the procedure indicated in Example 49b 47 g of a limpid pale yellow oil are prepared from 29 g (0.150 mol) of p-bromothiophenol and 32.2 g (0.165 mol) of ethyl 2-bromo-2-methylpropionate; subsequent purification of this oil (by distillation under reduced pressure) gives 40.8 g of ethyl 2-(p-bromophenylthio)-2-methylpropionate.

Workup

distillationsubsequent purification of this oil (by distillation under reduced pressure)

Sources & evidence

ORD record: ord-5ea1bdafd044475fa1307b359c81a732
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04156011

Reaction notes

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