HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → 1-Dimethylcarbamoyl-3,5-dipyrazinyl-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(5-pyrazin-2-yl-4H-1,2,4-triazol-3-yl)pyrazine | HCID 13524787 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Dimethylcarbamoyl-3,5-dipyrazinyl-1,2,4-triazole | HCID 20285780 | — |
Reaction Steps
To 2.25 g. (0.01 mole) of 3,5-dipyrazinyl-1,2,4-triazole in 200 ml. of tetrahydrofuran is added 57% sodium hydride (0.42 g., 0.01 mole). The reaction mixture is heated at reflux for one hour, cooled, and a solution of dimethylcarbamoyl chloride (1 gram, 0.01 mole) in 10 ml. of tetrahydrofuran is added dropwise. The reaction mixture is then refluxed four hours, cooled, filtered and concentrated to a solid. After recrystallization from benzene 1-dimethylcarbamoyl-3,5-dipyrazinyl-1,2,4-triazole is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04156085 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-586d2729ec4446138fe3f9a9f0e441c0 |
| Source note | uspto-grants-1979_05 |