反应详情

2-Aminopentanoic acid (0.2 mole) is added to a solution of sodium acetate (0.2 mole) in about 300 ml of glacial acetic acid. This solution is heated to effect solution and is then refluxed for 5 minutes. To the refluxing solution is added (0.2 mole) 2.5-dimethoxytetrahydrofuran as quickly as possible. The mixture is refluxed for a further 2 minutes and the acetic acid is flash evaporated. The residue is taken up in ethyl acetate, washed with water, dried and the solvent removed under vacuo to give 2-(1-pyrryl)pentanoic acid.

1. temperatureThis solution is heated
2. temperatureis then refluxed for 5 minutes
3. temperatureThe mixture is refluxed for a further 2 minutes
4. customevaporated
5. washwashed with water
6. customdried
7. customthe solvent removed under vacuo