Benzyloxyamine hydrochloride → 1-(Benzyloxy)-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

HRID 263183Notes

Reaction equation

HRID 263183 reaction equation
Cl.[CH2:2]([O:9][NH2:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[S:11]1[CH:15]=[CH:14][C:13]2[CH:16]([N:20]=[C:21]=[O:22])[CH2:17][CH2:18][CH2:19][C:12]1=2>>[CH2:2]([O:9][NH:10][C:21]([NH:20][CH:16]1[C:13]2[CH:14]=[CH:15][S:11][C:12]=2[CH2:19][CH2:18][CH2:17]1)=[O:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 102312Benzyloxyamine hydrochlorideHCID 205373014-Isocyanato-4,5,6,7-tetrahydro-1-benzothiophene

Product 1

HCID 203489141-(Benzyloxy)-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Procedure

In the manner described in Example 6, O-benzyl hydroxyamine hydrochloride and 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isocyanate are allowed to react to afford 1-(benzyloxy)-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, which is recrystallized from 95% ethyl alcohol-methyl isobutyl ketone. The product melts at 96.5° C. to 99° C.

Workup

  1. customto react

Sources & evidence

ORD record
ord-769e22b22e274148a8f3740f6a9d5919
Source dataset
uspto-grants-1979_05
Patent number
US04156670

Reaction notes

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