HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 26319Generated: October 27, 2026
Dimethylformamide → 2-Sulfo-2-(1-pyrryl)acetyl chloride
https://huagongshe.com/reaction/26319
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Sulfo-2-(1-pyrryl)acetic acid | HCID 86736465 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Sulfo-2-(1-pyrryl)acetyl chloride | HCID 86736467 | — |
Reaction Steps
2-Sulfo-2-(1-pyrryl)acetic acid is treated with thionyl chloride in ether at room temperature according to the general procedure in J. Med. Chem., 15, 1105 (1972) until the evolution of gas stops. Dimethylformamide is added, the solution is warmed to about 40° C. for 1 hour. Then ether is added, followed by hexane and the solution cooled to about -25° C. 2-Sulfo-2-(1-pyrryl)acetyl chloride is isolated from the solvent by decantation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04148998 |
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| Source dataset | uspto-grants-1979_04 |
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| ORD ID | ord-e1561fb8a76442beaa3c4d1d9f935f62 |
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| Source note | uspto-grants-1979_04 |
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