Potassium cyanate → 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea
Reaction equation
Cl.[C:2]([C:5]1[S:9][C:8]2[CH2:10][CH2:11][CH2:12][CH:13]([NH2:14])[C:7]=2[CH:6]=1)(=[O:4])[CH3:3].[O-:15][C:16]#[N:17].[K+]>O>[C:2]([C:5]1[S:9][C:8]2[CH2:10][CH2:11][CH2:12][CH:13]([NH:14][C:16]([NH2:17])=[O:15])[C:7]=2[CH:6]=1)(=[O:4])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A sample of 6.3 grams of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride is dissolved in 35 ml. of water and cooled to 15° C. A solution of 2.64 grams of potassium cyanate in 35 ml. of water is added, and after 0.5 hour the mixture is heated at 70° C. for about 40 minutes. The mixture is cooled, and the solid is collected and washed with water. On drying, 5.55 grams, melting point 218° C. to 220° C., of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea is obtained.
Workup
- temperatureThe mixture is cooled
- customthe solid is collected
- washwashed with water
- customOn drying
Sources & evidence
- ORD record
- ord-0602b9856abc45ba99cb6eaa87e5a14b
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04156670
Reaction notes
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