Magnesium monoxide → HCID 20348958, compound

HRID 263198Notes

Reaction equation

HRID 263198 reaction equation
[CH3:1][NH:2][C:3]([NH:5][C:6]1([CH3:16])[C:14]2[CH:13]=[CH:12][S:11][C:10]=2[CH2:9][CH2:8][CH:7]1I)=[O:4].[O-2].[Mg+2].[H][H]>[Pd].CO>[CH3:1][NH:2][C:3]([NH:5][C:6]1([CH3:16])[C:14]2[CH:13]=[CH:12][S:11][C:10]=2[CH2:9][CH2:8][CH2:7]1)=[O:4]

Participants

6

Reactant 3

HCID 6850729Magnesium monoxideHCID 20348909HCID 20348909, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20348958HCID 20348958, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Deiodination of 1-methyl-3-(5-iodo-4-methyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea is accomplished by treating a methanol mixture of this compound with palladium on carbon and magnesium oxide in a Paar hydrogenator at 50 psig. After uptake of the hydrogen is completed, the mixture is filtered through diatomaceous earth and filtrate is evaporated to dryness to afford 1-methyl-3-(4-methyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, melting point 135° C. to 145° C.

Workup

  1. additionby treating
  2. filtrationthe mixture is filtered through diatomaceous earth and filtrate
  3. customis evaporated to dryness

Sources & evidence

ORD record
ord-e730de89a30a4fc89636710b49169f40
Source dataset
uspto-grants-1979_05
Patent number
US04156670

Reaction notes

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