HCID 20348888, compound → HCID 20348952, compound

HRID 263199Notes

Reaction equation

HRID 263199 reaction equation
[CH3:1][NH:2][C:3]([NH:5][CH:6]1[C:14]2[CH:13]=[CH:12][S:11][C:10]=2[CH2:9][CH2:8][CH:7]1[CH2:15]C)=[O:4].CNC(NC1C2C=CSC=2CCC1CCC)=O.CNC(NC1C2C=CSC=2CCC1CCCC)=O>>[CH3:1][NH:2][C:3]([NH:5][CH:6]1[C:14]2[CH:13]=[CH:12][S:11][C:10]=2[CH2:9][CH2:8][CH:7]1[CH3:15])=[O:4]

Participants

4

Reactant 3

HCID 20348888HCID 20348888, compoundHCID 20348899HCID 20348899, compoundHCID 20348939HCID 20348939, compound

Product 1

HCID 20348952HCID 20348952, compound

Procedure

Similarly, alkylation of 4,5,6,7-tetrahydrobenzo[b]thiophen-4-one with ethyl iodide, propyl iodide, and butyl iodide affords the corresponding 5-alkyl ketones, which are converted in the above manner to 1-methyl-3-(5-ethyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, 1-methyl-3-(5-propyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, and 1-methyl-3-(5-butyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, respectively.

Sources & evidence

ORD record
ord-95c6021d8dfd4b5db24ca2794e285c7c
Source dataset
uspto-grants-1979_05
Patent number
US04156670

Reaction notes

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