Ethanol hydrochloride → 4,5,6,7-Tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride

HRID 263208Notes

Reaction equation

C([NH:3][CH:4]1[C:12]2[CH:11]=[CH:10][S:9][C:8]=2[C:7](=[O:13])[CH2:6][CH2:5]1)=O.[ClH:14].C(O)C>>[ClH:14].[O:13]=[C:7]1[C:8]2[S:9][CH:10]=[CH:11][C:12]=2[CH:4]([NH2:3])[CH2:5][CH2:6]1

Participants

Reactant 2

HCID 21887872Ethanol hydrochloride

HCID 23347790N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

Product 1

HCID 233477954,5,6,7-Tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride

Procedure

In the manner described in Example 36, N-formyl-4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine is hydrolyzed with 2 N hydrochloric acid/ethanol to afford 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride, melting point 230° C. to 232° C. (dec.).

Sources & evidence

ORD record: ord-ffc5690b8c9e47da86c43d2bea01eed1
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04156670

Reaction notes

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