Sodium Hydroxide → 4-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

HRID 263209Notes

Reaction equation

HRID 263209 reaction equation
Cl.[O:2]=[C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([NH2:12])[CH2:5][CH2:4]1.[OH-].[Na+]>O>[O:2]=[C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([NH2:12])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 233477954,5,6,7-Tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride

Product 1

HCID 233477964-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The free amine is obtained by neutralizing the amine hydrochloride in water with sodium hydroxide solution. It is separated by extraction with CHCl3 and removal of the CHCl3 in vacuo affords 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine.

Workup

  1. customIt is separated by extraction with CHCl3 and removal of the CHCl3 in vacuo

Sources & evidence

ORD record
ord-2bad3d0d21a04566a5356ca6bffb50e8
Source dataset
uspto-grants-1979_05
Patent number
US04156670

Reaction notes

Loading…