Trifluoroacetic acid → 3-[(Acetyloxy)methyl]-7-[[2-carboxy-2-(1-pyrryl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

3-[(Acetyloxy)methyl]-7-[[2-carboethoxy-2-(1-pyrryl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid is added to trifluoroacetic acid (TFA) maintained at 0° C. This mixture is stirred for about 30 minutes, warmed to about 20° C. for about 30 minutes and then warmed (maximum of 25° C.) under vacuum to remove the TFA. The acid is taken up in ethyl acetate. The ethyl acetate is washed with water, dried over magnesium sulfate, filtered and partially concentrated. The title compound was recovered from the solvent by filtration.

Provenance & Evidence