Ammonia → HCID 70608468, compound

Participants

Reaction Steps

A solution of 25.4 g (92.7 mmol) of the amine of Example 1 in 100 ml ether is added to 1 liter liquid ammonia. Lithium (10.0 g) is added portionwise over a period of 10 minutes. After stirring 30 minutes, absolute ethanol is added dropwise until the color is discharged (140 ml added in 1 hour). More ether is added and the ammonia is boiled off. While cooling in an ice bath, the mixture is diluted with 1 liter water. The layers are separated and the aqueous is reextracted with ether. The combined organic layers are dried over K2CO3, filtered, and the solvent is removed in vacuo leaving 27 g of the title compound in the form of an oil.

Provenance & Evidence