HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-3-methoxypyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (3-Methoxypyridin-2-yl)methanol | HCID 5324774 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(Chloromethyl)-3-methoxypyridine hydrochloride | HCID 20474208 | — |
Reaction Steps
2-Hydroxymethyl-3-methoxypyridine (4.2 g) was dissolved in chloroform (60 ml) and to the stirred solution was added thionyl chloride (6 ml). The mixture was stirred for 90 minutes and the solvent evaporated and the residue was recrystallised from ethanol/ether to give 2-chloromethyl-3-methoxypyridine hydrochloride (5.1 g), m.p. 171.5°-172.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04156727 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-ffc4a63aef364ac1bddee86b346a8749 |
| Source note | uspto-grants-1979_05 |