HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-methyl-N'-[2-(3-methoxy-2-pyridylmethylthio)ethyl]guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-{[(3-Methoxypyridin-2-yl)methyl]sulfanyl}ethan-1-amine | HCID 12951535 | — |
| Reactant | N-carbamimidoylbenzamide | HCID 178513056 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-methyl-N'-[2-(3-methoxy-2-pyridylmethylthio)ethyl]guanidine | HCID 178485114 | — |
Reaction Steps
A solution of 2-[2-aminoethylthiomethyl]-3-methoxypyridine in ethanol is added to a stirred solution of N-benzoyl dimethyldithioimidocarbonate in ethanol and the mixture is stirred overnight at room temperature. The purified product is treated with methylamine in ethanol and the resultant benzoylguanidine is hydrolysed by refluxing with aqueous hydrochloric acid to give N-methyl-N'-[2-(3-methoxy-2-pyridylmethylthio)ethyl]guanidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04156727 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-35171ba44e054624a07473fb253992a9 |
| Source note | uspto-grants-1979_05 |