Hydrochloric Acid → HCID 54487876, compound

Participants

Reaction Steps

A solution of N,N-dibenzyl-5-amino-pentan-2-one ethylene acetal (90 g) in ethanol (500 ml) containing dilute hydrochloric acid (200 ml) was refluxed for 1 hour. The solution was allowed to cool and the ethanol was evaporated in vacuo. The residue was dissolved in water and extracted with ether. The aqueous layer was made alkaline with dilute sodium hydroxide solution and was extracted twice with ether. The combined ethereal extracts were washed with water, dried over anhydrous sodium sulphate and evaporated in vacuo, to give a brown oil. The product was purified by chromatography to give N,N-dibenzyl-3-aminopropylmethyl ketone as a red-brown oil (60 g).

Provenance & Evidence