Ammonia → 2-(4-Chloro-3-sulfamoylbenzoyl)-benzo[b]furan

HRID 263292Notes

Reaction equation

HRID 263292 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[CH:9]=2)=[O:7])=[CH:4][C:3]=1[S:19](Cl)(=[O:21])=[O:20].[NH3:23]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[CH:9]=2)=[O:7])=[CH:4][C:3]=1[S:19](=[O:21])(=[O:20])[NH2:23]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 213166102-(4-Chloro-3-chlorosulfonylbenzoyl)-benzo[b]furan

Product 1

HCID 213165932-(4-Chloro-3-sulfamoylbenzoyl)-benzo[b]furan

Procedure

3.3 g 2-(4-Chloro-3-chlorosulfonylbenzoyl)-benzo[b]furan are introduced into 19 ml 25% aqueous ammonia solution, and after standing overnight, the liquid is distilled off. After addition of water, the pH is adjusted to 6 by means of dilute HCl, agitation is continued for a further 30 minutes, and the product is crystallized from a small amount of glacial acetic acid. Colorless crystals, m.p. 181° C.

Workup

  1. distillationthe liquid is distilled off
  2. additionAfter addition of water
  3. waitis continued for a further 30 minutes
  4. customthe product is crystallized from a small amount of glacial acetic acid

Sources & evidence

ORD record
ord-ae9b2c5a64b24301aaf0731e98068a00
Source dataset
uspto-grants-1979_05
Patent number
US04156732

Reaction notes

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