Benzo(B)Thiophene → HCID 21316617, compound

Participants

Reaction Steps

5.1 g of powdered 4-chloro-3-sulfamoylbenzoyl chloride are introduced into a solution of 3 g benzo[b]thiophene in 50 ml anhydrous toluene, and subsequently, 12 g titanium tetrachloride are added with agitation. Agitation is continued for 15 minutes at room temperature, the mixture is heated to boiling for about 15 minutes, cooled and poured onto a water/ice suspension. Extraction is carried out then with 70 acetic ester, the organic phase is separated and stirred for 5 hours with an aqueous sodium bicarbonate solution having a pH of 8.5. After separation of the organic phase and drying thereof over magnesium sulfate, the solvent is distilled off and the residue crystallized from toluene. M.p. 154°-156° C.

Provenance & Evidence