Iodine → 4-[(4-Hydroxyphenyl)disulfanyl]phenol

Participants

Reaction Steps

A solution of 4-mercaptophenol (200 g., 1.6 m.) in 300 ml. 60% aqueous ethanol was brought to pH 7 by the addition of sodium bicarbonate. A solution of iodine (200 g., 0.8 m.) and potassium iodide (50 g.) in 300 ml. water was added until a yellow end point was reached. The product was filtered off, washed with water and dried. Yield: 97.5%, mp. 144°-6° (lit. 148°-50°). The 1H nmr was consistent with the disulfide structure of the formula: ##STR2##

Provenance & Evidence