HCID 178461557, compound → HCID 178461556, compound

HRID 263307Notes

Reaction equation

HRID 263307 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][CH2:11][C@H:12]([CH3:14])[N:13]=2)=[CH:5][C:4]=1[N+:15]([O-])=O>CO.[Ni]>[ClH:1].[NH2:15][C:4]1[CH:5]=[C:6]([C:9]2[NH:10][CH2:11][C@H:12]([CH3:14])[N:13]=2)[CH:7]=[CH:8][C:3]=1[NH2:2]

Participants

4

Reactant 1

HCID 178461557HCID 178461557, compound

Product 1

HCID 178461556HCID 178461556, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

51 g of 2-(4-amino-3-nitrophenyl)-4(5)-methyl-2-imidazoline-hydrochloride are hydrogenated in 1 l of methanol with Raney-nickel at room temperature. After termination of the hydrogen absorption, the catalyst is filtered off with suction and the filtrate is brought to dryness under reduced pressure. The remaining oil is recrystallized from isopropanol. Yield: 42.6 g (corresponding to 94% of theor. yield),

Workup

  1. customAfter termination of the hydrogen absorption
  2. filtrationthe catalyst is filtered off with suction
  3. customThe remaining oil is recrystallized from isopropanol
  4. customYield: 42.6 g (corresponding to 94% of theor. yield)

Sources & evidence

ORD record
ord-dde16ededd414bb0a9283a99acf6c4e3
Source dataset
uspto-grants-1979_05
Patent number
US04156778

Reaction notes

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