Ethyl diazoacetate → HCID 67686033, compound

Participants

Reaction Steps

The reaction of trimethylphosphonoacrylate and ethyldiazoacetate was carried out as follows. Trimethylphosphonoacrylate (1.0 g, 5.15 mmol) was dissolved in methyl-t-butyl ether followed by ethyl diazoacetate (0.60 g, 5.26 mmol). After stirring overnight, the reaction was filtered and the resultant solid (880 mg, 55%) recrystallized from acetone-hexane to afford off-white granules of the pyrazoline 1H-Pyrazole-5-carboxylic-acid, 3-carboethoxy-5(dimethoxyphosphinyl)-4,5-dihydro, methyl ester (699 mg) mp 100°-102°.

Provenance & Evidence