Octanoyl chloride → 4-(S)-Isopropyl-3-(1-oxooctyl)-2-oxazolidinone

HRID 263446Notes

Reaction equation

HRID 263446 reaction equation
[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[NH:5]1)([CH3:3])[CH3:2].[C:10](Cl)(=[O:18])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>>[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10](=[O:18])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 8124Octanoyl chlorideHCID 7157133(4S)-4-(propan-2-yl)-1,3-oxazolidin-2-one

Product 1

HCID 108486184-(S)-Isopropyl-3-(1-oxooctyl)-2-oxazolidinoneYield 93.9%

Procedure

Following the procedure described in Referential Example 3, but using 4-(S)-isopropyl-2-oxazolidinone (5.06 g) and octanoyl chloride (6.67 g), the desired compound (9.39 g) was obtained.

Sources & evidence

ORD record
ord-ed776518fcc4420ba8ecedb84b43ae59
Source dataset
uspto-grants-1997_07
Patent number
US05643908

Reaction notes

Loading…