Hydrochloric Acid → HCID 19038071, compound

Participants

Reaction Steps

A solution of 2.30 g of 4-chloro-5-methyl-3-(3-quinuclidinyloxy)isoxazole (prepared as described in Example 1) in 30 ml of ethanol was cooled to 5° C. 2.50 ml of a 4N solution of hydrogen chloride in dioxane were then added dropwise to the solution. The resulting mixture was stirred at the same temperature for 10 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the solid residue thus obtained was recrystallized from isopropanol to afford 2.42 g (yield 91.6%) of the title compound as a colorless powder, melting at 195°-198° C. (with decomposition).

Provenance & Evidence