Potassium Iodide → HCID 19038248, compound

Participants

Reaction Steps

A mixture of 1.6 g (6 mmole) of 7-(3-chloropropoxy-3-(hydroxymethyl)chromen-4-one, 1.2 g (6 mmole) de 4-(p-fluorobenzoyl)piperidine, 2 g (14 mmole) of anhydrous potassium carbonate and 0.5 g of potassium iodide in 30 ml of acetonitrile was heated for 24 hours at reflux, allowed to cool, filtered, and the filtrate was evaporated to dryness. The residue was dissolved in dichloromethane, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and evaporated. The product was dissolved in acetone and precipitated by addition of a hydrogen chloride solution. The precipitate was collected by filtration, washed with acetone, and recrystallized from methanol-ethyl ether to give 0.5 g (18%) of a solid, melting point 217°-218° C. (d).

Provenance & Evidence