HCID 86747727, compound → HCID 6923529, compound

Participants

Reaction Steps

A thick-walled glass hydrogenation tube was charged with diastereomer B of 1-[((R)-α-methylbenzyl)oxycarbonyl]-trans-4,5-diphenyl-3-pyrazolidinone [from Example 139A/139B] (226 mg, 0.586 mmol), 15.0 mL THF and 5% Pd/C catalyst (112 mg) and was shaken on a Parr apparatus under an atmosphere of hydrogen at c. 50 psi pressure for 15.5 hr. The catalyst was filtered off using Celite and washed with THF. The tiltrate was evaporated in vacuo to obtain 134 mg (96%) of a white foam: 1H NMR (CDCl3) δ 3.99 (d, J=l 1 Hz, 1H), 4.66 (br s, 1H), 4.74 (d, J=11 Hz, 1H), 7.20-7.39 (m, 1 OH), 8.63 (br s, 1H).

Provenance & Evidence