HRID263498

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](CC(=O)OC1CCCCC1)C(=O)O.Cc1ccc(CO[C@H]2[C@H](O)[C@H](O)C(O)O[C@@H]2CO)cc1

HCID131720065

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(CO[C@H]2[C@H](O)[C@H](O)C(O)O[C@@H]2CO)cc1.N[C@@H](CC(=O)OC1CCCCC1)C(=O)O

HCID131720066

未命名化合物

收率 107.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21863450

未命名化合物

PROCEDURE

实验过程

Boc-Asp(O-cHex)-Man(4-MBzl) (52 g) was treated with 50% TFA/methylene chloride (400 mL) for 45 min at room temperature. The solvent was evaporated and chased several times with methylene chloride to eliminate traces of TFA. The product precipitated as its TFA salt upon addition of ether. The solid was collected and air dried to yield a white solid (46.7 g, 88%).

WORKUP

后处理

customThe solvent was evaporated
customThe product precipitated as its TFA salt upon addition of ether
customThe solid was collected
customair dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce3cf141d3b541f7b31680b4023b0da8
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05643872
来源说明: uspto-grants-1997_07

反应 SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4](=[O:12])[O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[OH:23][CH:24]1[O:40][C@H:39]([CH2:41][OH:42])[C@@H:29]([O:30][CH2:31][C:32]2[CH:38]=[CH:37][C:35]([CH3:36])=[CH:34][CH:33]=2)[C@H:27]([OH:28])[C@@H:25]1[OH:26]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:1][C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4](=[O:12])[O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[OH:23][CH:24]1[O:40][C@H:39]([CH2:41][OH:42])[C@@H:29]([O:30][CH2:31][C:32]2[CH:38]=[CH:37][C:35]([CH3:36])=[CH:34][CH:33]=2)[C@H:27]([OH:28])[C@@H:25]1[OH:26]