HCID 19038527, compound → HCID 19038512, compound

Participants

Reaction Steps

10% Palladium carbon (0.3 g) was added to 80 ml of ethyl acetate solution containing 4.76 g of 1-benzyloxy-1-(4-nitrobenzyl)urea. The reaction mixture was stirred overnight under normal pressure in an atmosphere of hydrogen, and then insoluble materials were removed by filtration. After evaporating the solvent under a reduced pressure, the resulting residue was purified by silica gel column chromatography (eluant: chloroform:methanol=10:1) to obtain 1.82 g of 1-(4-aminobenzyl)-1-benzyloxyurea.

Provenance & Evidence