Diethyl Ether → 3-Fluoro-p-anisaldehyde

To a solution of o-fluoroanisole, 101 g. (0.80 mole) in 500 ml. dry methylene chloride is added dropwise over 30 minutes a solution of titanium tetrachloride, 182 g. (0.96 mole, 1.2 equiv.) and α,α-dichloromethylmethyl ether, 110 g. (0.96 mole) in an equal volume of methylene chloride. The temperature is maintained at 10°-20° C. with an ice-bath. The mixture is stirred at room temperature for 1 hour longer and then poured over crushed ice-water with stirring. Ether (1 l.) is added, and the mixture stirred under nitrogen until solution occurs. The organic layer is extracted with water (3×), sodium bicarbonate solution (3×) and dried (MgSO4). The solvent is evaporated off at 30° to give crude product as an oil. The oil is vacuum distilled through a jacketed Vigreux column when it gives 3-fluoro-4-methoxybenzaldehyde, B.P. 120°-121° C., at 10 mm. Hg; Rf 0.6 on a silica-gel G plate with methylene chloride.

1. temperatureThe temperature is maintained at 10°-20° C. with an ice-bath
2. additionpoured
3. stirringwith stirring
4. stirringthe mixture stirred under nitrogen until solution
5. extractionThe organic layer is extracted with water (3×), sodium bicarbonate solution (3×)
6. dry with materialdried (MgSO4)
7. customThe solvent is evaporated off at 30°
8. customto give crude product as an oil
9. distillationdistilled through a jacketed Vigreux column when it

ORD record

ord-be6524fd1c0044f296996824ff7dc163

Source dataset

uspto-grants-1997_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05643959