Phthalic Anhydride → 2-(8-Chloro-2-methylquinolin-5-yl)-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

95 g of trichlorobenzene was added to 23.3 g (0.12 mole) of 8-chloro-5-amino-quinaldine and 18.0 g (0.12 mole) of phthalic anhydride, and the mixture was reacted under reflux for 2 hours at the boiling point. After cooling, the precipitated crystals were separated by filtration, and dried to afford 32 g (0.10 mole) of 8-chloro-5-phthalimidoquinaldine.

Provenance & Evidence