Tetrabromophthalic anhydride → 8-Methyl-5-(3,4,5,6-tetrabromophthalimido)-quinaldine

Participants

Reaction Steps

172 g (1.0 mole) of 5-amino-8-methylquinaldine and 464 g (1.0 mole) of 3,4,5,6-tetrabromophthalic anhydride were reacted in 2,000 g of trichlorobenzene for 2 hours under reflux to afford 532 g (0.86 mole) of 8-methyl-5-(3,4,5,6-tetrabromophthalimido)-quinaldine. 369 g (1.29 moles) of tetrachlorophthalic anhydride and 2,000 g of α-chloronaphthalene were added, and the mixture was reacted for 2 hours under reflux. The product was collected by hot filtration at 120° C., and dispersed in 1,000 g of α-chloronaphthalene, and the mixture was heated with stirring to wash the product. After hot filtration, the product was washed with ethanol and dried to afford 671 g (0.75 mole) of a yellow compound.

Provenance & Evidence