反应详情

A mixture of 50 grams of 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-4-amine hydrochloride in 100 ml. of water is stirred at about 15° C. and a solution of 23.1 grams of potassium cyanate in 100 ml. of water is added dropwise. After completion of the addition, the mixture is warmed slowly to 70°-75° C. and held there for one hour. The mixture is cooled and the white solid is collected by filtration and washed with water. The solid is air-dried, pulverized, and washed with acetonitrile. Upon drying, this crude product is treated with hot acetone whereby there is obtained 5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-4-ylurea, m.p. 217° C. dec.

1. additionAfter completion of the addition
2. temperaturethe mixture is warmed slowly to 70°-75° C.
3. temperatureThe mixture is cooled
4. filtrationthe white solid is collected by filtration
5. washwashed with water
6. customThe solid is air-dried
7. washwashed with acetonitrile
8. customUpon drying
9. additionthis crude product is treated with hot acetone whereby there