2-benzyl 3-tert-butyl (2RS,3RS)-5-oxotetrahydrofuran-2,3-dicarboxylate → (2RS,3RS)-3-tert-butoxycarbonyl-5-oxotetrahydrofuran-2-carboxylic acid

Participants

Reaction Steps

2.70 g of 2-benzyl 3-tert-butyl (2RS,3SR)-5-oxotetrahydrofuran-2,3-dicarboxylate was dissolved in 30 ml of ethyl acetate, and 300 mg of a 10% palladium-carbon catalyst was added thereto, followed by catalytic reduction for 3 hours at room temperature under hydrogen atmospheric pressure. The catalyst was filtered off, and the filtrate was evaporated to dryness under reduced pressure to obtain 1.86 g of the above-identified compound as white solid.

Provenance & Evidence