HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-Hydroxy-7-methoxy-5-benzofurancarboxaldehyde | HCID 21785684 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid | HCID 21785685 | — |
Reaction Steps
The aldehyde of Example 5 (192 mg., 1 mmole) in 1 ml. of water was added to a solution of ethyl cyanoacetate (125 mg., 1.1 mmole) in 1 ml. of water containing 200 mg. of sodium hydroxide. The mixture was stirred at room temperature for 20 hours then treated with 8 ml. of 2N HCl under reflux for 30 minutes. After cooling, the product was isolated by centrifugation followed by crystallization from ethanol to yield a yellow solid, m.p. 227°-228°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04150042 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-5a981ebacd3c470394ccc010da8f719e |
| Source note | uspto-grants-1979_04 |