Z-(L)-Tyr morpholin-4-ylamide → H-(L)-Tyr morpholin-4-ylamide

HRID 263763Notes

Reaction equation

HRID 263763 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[N:24]1([NH-:30])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>CO.[Pd]>[NH2:1][C@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1.[N:24]1([NH-:30])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

Participants

4

Reactant 1

HCID 131720080Z-(L)-Tyr morpholin-4-ylamide

Product 1

HCID 131720081H-(L)-Tyr morpholin-4-ylamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2.05 g (5.3 mmol) of Z-(L)-Tyr-morpholin-4-ylamide in 91 ml of methanol is hydrogenated for 1.5 h at RT in the presence of 0.5 g of 10% Pd/C. Filtration through ®Celite (filter aid of diatomaceous earth, John-Manville Corp.) and concentration of the filtrate by evaporation yields the title compound: TLC Rf (R)=0.34.

Workup

  1. filtrationFiltration
  2. filtrationthrough ®Celite (filter aid of diatomaceous earth, John-Manville Corp.) and concentration of the filtrate
  3. customby evaporation

Sources & evidence

ORD record
ord-a4ee66bf8b084a29874ed2e87eec0366
Source dataset
uspto-grants-1997_07
Patent number
US05643878

Reaction notes

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