反应详情

Hydrogenation in the presence of 1 g of 10% Pd/C for 1.5 h at RT of a solution of 4.83 g (10 mmol) of Z-(L)-Val-(L)-Tyr-morpholin-4-ylamide in 182 ml of methanol, followed by filtration through ®Celite, concentration of the filtrate by evaporation and column chromatography (SiO2, methylene chloride/methanol 9:1), yields the title compound: TLC Rf (F)=0.30; FAB-MS (M+H)+ =350.

1. filtrationfollowed by filtration through ®Celite, concentration of the filtrate by evaporation and column chromatography (SiO2, methylene chloride/methanol 9:1)