Lithium Hydroxide → 5(S)-(Boc-amino)-4(S)-hydroxy-6-cyclohexyl-2(R)-(4-benzyloxy-benzyl)-hexanoic acid

Participants

Reaction Steps

Analogously to Example 1 i), 2.4 g (4.728 mmol) of 5(S)-[1(S)-(Boc-amino)-2-cyclohexylethyl]-3(R)-(4-benzyloxybenzyl)-dihydrofuran-2-(3H)-one in 10 ml of 1,2-di-methoxyethane are reacted with 9.45 ml of 1M LiOH solution to yield the title compound, which is purified by crystallisation from hexane. TLC Rf (E)=0.33; tRet (IV)=18 min; FAB-MS (M+H+)=526.

Provenance & Evidence