HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Dimethylamino)butyric acid hydrochloride → 4-(Dimethylamino)butanoyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Dimethylamino)butyric acid hydrochloride | HCID 12691640 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | 4-(Dimethylamino)butanoyl chloride hydrochloride | HCID 19037478 | — |
Reaction Steps
10 g (60 mmol) of 4-dimethylaminobutyric acid hydrochloride (Janssen; Bruggen/Germany) are heated for approximately 3 h at 65° C. in 30 ml of SOCl2. SOCl2 is evaporated off and the residue is stirred to yield the title compound: TLC of a sample dissolved in methanol, Rf (U)=0.67; TLC of 4-dimethylaminobutyric acid hydrochloride, Rf (U)=0.50.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05643878 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-41aced89796c40338464e2b8252692e6 |
| Source note | uspto-grants-1997_07 |