HCID 131720085, compound → HCID 131720084, compound

Participants

Reaction Steps

A solution of 298 mg (0.48 mmol) of tert.-butyl 3-[(S)-7-benzyloxycarbonylamino-7-trimethylsilylethoxycarbonyl-5,6,7,8-tetrahydro-naphthalen-1-yloxy]nicotinate in 5 ml of ethanol was hydrogenated under a hydrogen atmosphere with 80 mg of palladium-charcoal (10%) at room temperature for 1 hour, whereupon the mixture was filtered over Hyflo and the filtrate was concentrated. The residue was dried in a high vacuum and chromatographed on 50 g of silica gel with chloroform/methanol (95:5), whereupon 190 mg (81.7%) of tert.-butyl 3-[(S)-7-amino-7-trimethylsilylethoxycarbonyl-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-nicotinate were obtained. MS (ISP): 485.5 (M+. +H+, 50), 429 (15), 401.3 (100).

Provenance & Evidence