HCID 22874560, compound → HCID 22874559, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-4 (0.43 g, 0.95 mmol) was suspended in EtOAc (15 mL) and cooled to -78° C. HCl gas was bubbled through the solution and the solution became homogenous. The solution was placed in an ice bath for 0.5 h, then concentrated to give 2-5 as an amorphous yellow solid. 1H NMR (300 MHz, CD3OD) δ8.97 (d, 1H), 8.62 (d, 1H), 8.44 (d, 1H), 8.18 (d, 1H), 7.95 (t, 2H), 4.25 (dd, 1H), 3.52 (s, 6H), 3.35 (dd, 1H), 3.12 (dd, 1H), 3.06 (s, 3H).

Provenance & Evidence