HCID 19035377, compound → HCID 10763262, compound

Participants

Reaction Steps

5-3 (2.0 g, 5.27 mmol) was treated with NaClO2 (5.27 g, 58.3 mmol) with stirring at room temperature for 16 h. The reaction mixture was concentrated and partitioned between EtOAc (10 ml) and 3 ml of 1N NaHSO4. The organic phase was dried (MgSO4), concentrated and the solvent was removed. The residue was triturated with hexane to provide 5-4. as a white solid. 1H NMR (300 MHz, CD3OD) δ1.17 (2H, m), 1.46 (9H, s), 1.70 (4H, m), 2.68 (2H, t), 2.92 (2H, t), 4.10 (2H, bd), 6.95 (1H, s), 7.94 (1H, s).

Provenance & Evidence